The trade war between the United States (U.S.) and the People's Republic of China (PRC) that began in 2018 has seen a critical increase in the role of global supply chains, a fact reflected in U.S. federal law. The aim of this article is to test the hypothesis that supply chain management security is one of the most crucial components of the U.S. global supply chain management strategy. This security can be significantly ensured by overcoming three of the most significant and dominant challenges: resilience, variability, and complexity. These challenges have found their way not only into public policies but also into federal law, making them the foundation of a strategic approach. Planning, implementation, and coordination activities are systematically developed, with the common denominator being the use of artificial intelligence for predictive, adaptive, and data integration, enabling a redefinition of U.S. global supply chains.